Uruguay's game against the reigning European champions will be held at Sochi's Fisht Stadium on Sunday (4am AEST).

Pepe was Spanish side Real Madrid defender from 2007 to 2017, while Suarez joined bitter rivals Barcelona in 2014.

"Pepe played for Real Madrid for many years, but for me this game won't be limited to an individual confrontation with him. The match won't be easy, we'll play against the European champions. There might be the possibility to take advantage of individual talent in a one-on-one scenario, but it's still a game of eleven against eleven, which we are preparing for," Suarez said.

The 2018 FIFA World Cup kicked off on June 14 and will continue until July 15, with the matches being played in 11 cities across Russia.