Santiago Ezquerro put Frank Rijkaard's team in control with two goals in the first 10 minutes but the underdogs responded well after the break and secured a memorable draw through a Jorge Perona penalty and a last-minute equaliser from substitute Carlos Arnau.

Real Madrid left it late but clinched their place in the next round thanks to a 2-1 win over third division Alicante to edge the overall tie 3-2. Guti netted the decisive last-gasp winner for the Spanish champions.

Villarreal were also late 2-1 winners on Wednesday against Las Palmas, but had the cushion of a 4-2 first-leg lead to ease their nerves.

Holders Sevilla needed a last-minute goal from Frederic Kanoute to beat Denia 4-3 and secure their place in the last 16.

After a 1-1 in the first leg, Manolo Jimenez's team looked to have done the hard work when they went 2-0 up within half an hour of the second meeting thanks to goals from Luis Fabiano and Federico Fazio.

Denia hit back to go 3-2 up through goals from Alemany Jose Jaime, Laget Gregory and Soler Migue before two goals in the last four minutes from Ernesto Chevanton and Kanoute turned the tie in the top-flight side's favour.

Valladolid prevailed 3-2 at Real Murcia to advance 4-3 on aggregate.

The fourth-round tie between Deportivo La Coruna and Espanyol was the only one which required extra time after the second leg - like the first - finished 1-1.

Substitute Raul Tamudo produced the crucial goal in the 105th minute to give the Barcelona outfit the win at the Riazor.

In another all-Primera Liga tie, Real Mallorca overturned a 2-0 first-leg deficit in emphatic style with a 4-0 triumph at home in the second encounter.

Last year's runners-up Getafe ran out 4-1 winners at home to clinch a 5-1 aggregate triumph over third division Burgos.

Recreativo Huelva were held to a 1-1 draw at home by Xerez but advance thanks to their 1-0 away win in the first meeting.

Atletico Madrid could only manage a 1-1 draw at home to Granada 74 but progress 3-2 on aggregate.

Real Betis were comfortable 3-0 victors against second division Elche to go through 4-1 overall.

After neither side could muster a goal in the first leg, Racing Santander edged Malaga 2-0 to claim their last-16 berth.

Two second-half goals gave Athletic Bilbao a 2-0 win over Hercules to secure them a 4-2 aggregate victory, while Valencia overcame Real Union Irun 3-0 to go through 5-1.