Although it took them until the 42nd minute to break the deadlock through Ibrahim Afellay's goal, the floodgates opened soon after as Nordin Amrabat and Danny Koevermans made it 3-0 before half-time and Afellay added another soon after the break.

Koevermans then added his second and PSV's fifth 13 minutes from time.

Rafael Uiterloo scored in the 90th minute but it was scant consolation for the hosts.

Marco van Basten suffered a losing start to his coaching career at Ajax after they conceded a half-time lead to fall to a 2-1 defeat at Willem II.

Taking charge of his first game since leaving the Holland manager's job following Euro 2008, Van Basten saw one of his summer signings, Miralem Sulejmani, open the scoring in the 22nd minute.

The Amsterdammers could have had more than Sulejmani's strike to show for a dominant opening period and they were made to pay for their profligacy as second-half goals from Frank Demouge and Mehmet Akgun consigned Van Basten to defeat.

The former AC Milan striker's day was soured further when Evander Sno, another new face at Ajax this season, was shown a straight red card six minutes from time.

Late goals from Rutger Worm - who was sent-off after collecting a second yellow card for over-celebrating - and Mark Otten enabled NEC Nijmegen to beat De Graafschap 2-0, while Roda JC and FC Twente drew 1-1.

Eljero Elia put Steve McClaren's Twente side ahead but Andres Oper levelled for the hosts with six minutes to go.