Table toppers AZ Alkmaar were forced to settle for a point at Ajax, while PSV Eindhoven moved into second in the Eredivisie on Saturday.
Reigning champions Ajax came from behind to record a 2-2 draw at the Amsterdam Arena.
Attacker Brett Holman gave visitors AZ an early lead with a deflected strike from the edge of the area, before the Australian turned provider for Roy Beerens to double their lead.
But Ajax fought back after the break to net twice.
Serbian forward Miralem Sulejmani fired home from the penalty spot and Theo Janssen helped the Amsterdam giants to a hard-fought draw despite the dismissal of midfielder Eyong Enoh.
Elsewhere, PSV made it seven-straight league games unbeaten with a hard-fought 1-0 win over Utrecht.
Sweden striker Ola Toivonen struck with a low shot from 20 yards on 71 minutes to give the hosts the lead at Philips Stadion, and Utrecht were reduced to 10 men soon after when Marcus Nilsson was sent off for denying a goal-scoring opportunity.
Twente sit third after a Marc Janko hat-trick led them to a 4-0 thrashing of RKC Waalwijk.
The Austria international opened the scoring before the break and netted twice in the second half, with Wout Brama adding a fourth as Twente romped to a convincing win over the ninth-placed Waalwijk.
Seventh-placed Heracles extended their unbeaten run to four matches with a 2-1 win over Groningen.
Lerin Duarte and Suk Hyun-Jun traded goals before Willie Overtoom struck an 80th-minute winner to leave Groningen sitting in eighth.
Heerenveen and De Graafschap played out a 1-1 draw, with the former's Belgian midfielder Sven Kums and the latter's Michael de Leeuw trading goals just before half-time.
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