Seven goals, three red cards and the second time in A-League history a side has come back from three goals down to win.
Isaias notched one back for the Reds with the last act of the first half, placing a free-kick perfectly into the top left corner. As the second half wore on Adelaide became increasingly dominant and Brisbane began to fall apart.
First Jai Ingham received his second yellow card, both needlessly, then minutes later Jamie Young was sent off as well.
Craig Goodwin then made it 3-2 as Adelaide sensed blood, before George Blackwood and Nikola Mileusnic rounded out the 4-3 win, the winner coming in the 97th minute.
In taking out the match, Adelaide become only the second team in A-League history to come back from three goals down to win.
"I'm so glad and I'm so proud of the boys," Isaias said.
"I never thought it was done, in football anything can happen."
But while Hindmarsh Stadium erupted at a sensational display of theatre, Brisbane Roar remain winless under Darren Davies' eight match tenure.
"It's not great, obviously," Matt McKay said.
"We had that game totally under control, what can you say? We're a team that doesn't know how to win at the moment and it showed.
"Ingham's a young boy, I've done it before, everyone makes mistakes. We get behind him, we'll keep trying, we're professionals."