Derby held a two-goal advantage early in the first half at Pride Park, after headers from Richard Keough and Jake Buxton.

The lead was extended to three goals when Theo Robinson converted a strike from the six yard box in the 40th minute.

Derby held a 4-1 lead through an hour of play, but Scunthorpe edged back into the game to trail 4-3 with less than 20 minutes remaining, as Bobby Grant found the left corner from deep inside the penalty box in the 73rd minute.

A Nathan Tyson header for Derby in the 83rd, however, restored the hosts' two-goal advantage, to seemingly ice the tie.

But two goals deep into injury time to Connor Jennings and Grant saw the visitors into extra-time, which ended scoreless, before they denied the hosts 7-6 in the shoot-out.

Birmingham routed Barnet 5-1 after scoring four goals in a dominant second-half performance.

Barnet took the lead when Joe Nurse finished a header in the 31st minute.

Marlon King responded for Birmingham equalising from the penalty spot, to leave it all-square at the interval.

A powerful strike from Steven Caldwell in the 49th gave Birmingham the lead soon after the break.

Darren Ambrose soon extended the margin to two goals in the 54th minute with a finish from outside the box into the bottom right corner.

Injury-time goals from Peter Lovenkrands and Wade Eliot sealed Birmingham's progression.

In other results, Championship sides Crystal Palace and Leicester City both had wins, with the former coming from behind to beat Exeter 2-1, and City thrashing Torquay 4-0.

Milwall were not as fortunate, as they succumbed to Crawley Town on penalties, after regulation and extra-time ended 2-2.

A 120th-minute winner from Abdulai Bell-Baggie secured Tranmere progression past Chesterfield 2-1.

Portsmouth went down to Plymouth 3-0, while an Alex Nicholls header in the 48th minute delivered Northampton Town a 2-1 victory over last season's runners-up Cardiff City.

Burnley beat Port Vale 3-1 away from home, Ipswich Town accounted for Bristol Rovers 3-1 while Stevenage got past AFC Wimbledon by the same scoreline.

Yeovil Town were comfortable 3-0 victors over Colchester United, while Gillingham progressed past Bristol City 2-1 away from home and Coventry City edged Dagenham & Redbridge 1-0 away also.

Plymouth Argyle dismissed Portsmouth 3-0, Peterborough thrashed Southend United 4-0, Swindon Town impressed in a 3-0 win over Brighton & Hove Albion, Oxford United edged AFC Bournemouth on penalties and Leyton Orient also won a shootout against Charlton Athletic.