Defender Maldini, who has won European football's premier club competition with the Rossoneri on four occasions, has a left knee injury and is set to be replaced by Kahka Kaladze.

Milan coach Carlo Ancelotti told the club's television channel: "Paolo Maldini will remain in the team's training camp even though he's not available for tomorrow's game."

United won the first leg 3-2 at Old Trafford.