Anderson and Jonny Evans will be missing for three weeks with ankle injuries, while Nani is also absent from the squad which defeated Derby County on Tuesday.

Nani will be sidelined for at least a week with a groin strain, Park Ji-sung (hamstring) will not figure either and Gary Neville and Ryan Giggs are slight doubts.

Young defenders Adam Eckersley, Fabio and James Chester have been added to Sir Alex Ferguson's squad, with Darren Fletcher set to start at right-back.

Team (from): Van der Sar, Kuszczak, Foster, Fletcher, Eckersley, Fabio, Chester, Neville, Vidic, O'Shea, Gibson, Possebon, Tosic, Ronaldo, Carrick, Scholes, Giggs, Tevez, Berbatov, Welbeck, Macheda.