The Saints, who beat Premier League side Blackpool 2-0 yesterday, will face Sir Alex Ferguson's men at St Mary's on the weekend of January 29/30.

There could be as many as five all top-flight ties, with Bolton drawn at home to Wigan, Fulham up against Tottenham, winners over Charlton today, and Aston Villa taking on Blackburn.

Holders Chelsea will travel to Everton, while the winners of the replays between Doncaster and Wolves and Stoke and Cardiff will meet.

League Two side Stevenage, who caused the shock of the round by beating Newcastle 3-1 yesterday, will welcome Reading to the Lamex Stadium, while Birmingham take on Coventry in a midlands derby.

Leeds and Arsenal will replay next week with a home tie against League One promotion hopefuls Huddersfield awaiting the winner, while West Ham will be at home to Nottingham Forest and Watford play Brighton.

The winners of Manchester City's replay with Leicester will head to Notts County, surprise winners at Sunderland yesterday, while Swansea will play Leyton Orient and Burton Albion will travel to Burnley.

The winner of tomorrow's game between Crawley and Derby will head to Torquay, while Sheffield Wednesday will be at home to the winner of the replay between Wycombe and Hereford.