The Rossoneri go into the clash with the promoted outfit on the back of a 3-2 home defeat to the Premier League side in the opening leg of their Champions League last-16 tie.

"It's not over," said Leonardo of the European encounter.

"It would have been easier to travel to Manchester having a different score.

"But my team displayed a good performance and I am confident that it can go to Old Trafford and do well."

The return clash at Old Trafford is on March 10, meaning Milan can retrain their focus on to domestic matters in the meantime.

They remain in the title race, although their first aim is to leapfrog Roma into second place in the standings.

That will be no easy task, though, as Roma, who are two points ahead of Leonardo's men, are in great form at present.

They host Catania on Sunday looking to make it seven wins in a row.

The Giallorossi's terrific form has seen them pull within seven points of leaders and defending champions Inter Milan.

Inter also go into their game at Sampdoria with one eye on next week's Champions League tie against Chelsea.

Fourth-place Napoli will be confident of ending their three-match winless run when they make the journey to Tuscany to face rock-bottom Siena.

Napoli need to prevail to be certain that Sampdoria and Juventus do not overtake them in the standings.

Samp are level on 39 points with Napoli while Juve trail one point behind them.

Juve will be looking to build on their first win under coach Alberto Zaccheroni when they travel to Bologna on Sunday.

The Bianconeri won 3-2 in a controversial clash with Genoa last weekend.

Bologna will have to do without injured top-scorer Marco Di Vaio.

Fiorentina face relegation-threatened Livorno in a Tuscan derby looking to bounce back from Wednesday's 2-1 Champions League setback at Bayern Munich.

The Viola's last victory was on January 10.

Udinese visit Genoa on Saturday still searching for their first win on the road this season.

The Friuli outfit are one point clear of the drop zone and have claimed just four points on their travels this term.

Palermo will fancy their chances of claiming all three points against Lazio on Sunday with the Sicilian outfit unbeaten at La Favorita this season.

The Rosaneri lie seventh in the standings, just one point behind Juve, who hold the last European qualifying spot.

Chievo will look to increase their six-point advantage over the drop zone with a win at Atalanta.

The men from Verona are desperate to end a four-match winless streak in Bergamo.

Cagliari and Parma will square off in Sardinia in a mid-table clash.

The Rossoblu are five points clear of Parma in the standings.