Goals from Dimitris Salpingidis (18), Djibril Cisse (74) and Sebastian Leto (89) moved Pana six points clear of Olympiacos with two games to go.

Atromitos had Marcello Oliveira sent off in the 73rd minute.

Olympiacos could only manage a goalless draw at home to FC Xanthi, but remained second as PAOK Salonika went down 2-1 at Larissa.

Daniel Cousin had given Larissa the lead in the 16th minute, while they finished the game with 10 men following the sending-off of Panagiotis Katsiaros in the 90th minute.

Substitute Sander Puri scored the winner in the 90th minute after Pablo Contreras's 83rd-minute leveller looked to have snatched a point for PAOK.

Ignacio Scocco scored in the 90th minute to rescue a 1-1 draw for fourth-placed AEK Athens at home to Panionios, who went ahead through Fanouris Goundoulakis but had Lorenzo Sito Riera sent off four minutes from time.

Elsewhere, Aris Salonika beat Levadiakos 1-0, Asteras Tripoli defeated Panthrakikos 3-1, Iraklis were 2-0 winners over Giannina and Ergotelis claimed a 3-1 success at Kavala.