Ramos has endured a few scares winning the competition with Sevilla in the past two seasons - goalkeeper Andres Palop scored at this stage a year ago - and this time Berbatov appeared to have come to his rescue.

His ferocious drive cancelled out PSV's advantage from the first leg before the shoot-out, with PSV earning a place in the quarter-finals after Jermaine Jenas and Pascal Chimbonda failed from the spot.

Jenas had the chance to send the Londoners through to the quarter-finals only to see his penalty well saved by PSV goalkeeper Heurelho Gomes, before Chimbonda screwed his penalty wide.

Everton followed their English counterparts out of the competition on penalties after battling back against Fiorentina.

The hosts grabbed their first goal when Fiorentina goalkeeper Sebastien Frey struggled to clear a cross from Steven Pienaar and Andy Johnson bundled in with his shoulder from close range. Mikel Arteta struck a superb 25-yard drive to level the tie after 67 minutes, which would ultimately send the game to penalties.

And it was the Italian side who would prevail 4-2 on penalties as first Yakubu saw his spot-kick rebound back of the post before Frey saved Phil Jagielka's effort.

Bayer Leverkusen moved a step closer to their second UEFA Cup title after seeing off Bundesliga rivals Hamburg despite a 3-2 loss in their last-16 second leg.

Leverkusen twice went ahead through Sergej Barbarez (18) and Theofanis Gekas (55) only to see Hamburg equalise with strikes from Piotr Trochowski (53) and Jose Paolo Guerrero (64).

Rafael van der Vaart gave Hamburg the lead in the 80th minute but it was not enough for the hosts as Leverkusen, UEFA Cup champions in 1998, moved into the last eight on the away goals rule.

Zenit St Petersburg also booked their place in the next round on away goals thanks to Pavel Pogrebnyak's brace in a 2-0 home win against Marseille.

Juan Angel Albin's second-half strike earned Getafe a 1-0 win over Benfica as they deservedly progressed 3-1 on aggregate.

Bayern Munich advanced despite losing their home return leg 2-1 against Anderlecht.

Bayern built on their 5-0 first leg victory in Brussels when Lucio put them ahead on the night, but a 20th-minute equaliser from Serhat Akin and an Oleksandr Yakovenko strike 10 minutes before half-time gave Anderlecht victory.