Hamit Altintop opened the scoring in the first leg of the last-16 clash after just nine minutes and Luca Toni added a second on the stroke of half-time.

Lukas Podolski, Miroslav Klose and substitute Franck Ribery all struck after the break to seal a comprehensive win.

The Belgian side played the entire second-half with 10 men after Marcin Wasilewski was sent off for two yellow cards in as many minutes.

Djibril Cisse scored in either half to help Marseille take a 3-1 lead into the second leg of their clash with Zenit St Petersburg.

The France striker netted low finishes either side of a Mamadou Niang effort before Andrei Arshavin slotted an away goal for Zenit in the 82nd minute.

UEFA Cup debutants Getafe held on for a 2-1 win over 10-man Benfica in the Stadio da Luz.

Oscar Cardozo was sent off early on before Getafe took a commanding lead through Ruben De La Red and Pablo Hernandez.

Pedro Manuel Mantorras pulled one back for Benfica with 15 minutes to go, but the Portuguese side still have a big job to do in Spain.

Bolton will have to conjure another of their away-day specials if their European adventure is to continue.

The odds of reaching the quarter-finals are now stacked heavily in favour of Sporting Lisbon after Simon Vukcevic cracked a stunning equaliser to cancel out Gavin McCann's first-half opener in a 1-1 draw.

Two memorable second-half strikes from Zdravko Kuzmanovic and then Riccardo Montolivo eased Fiorentina to a well-deserved 2-0 victory against Everton.

Elsewhere, Steve Davis opened his goalscoring account as Rangers took a major step towards the last eight with a 2-0 win over Werder Bremen at Ibrox.

Davis sealed the win early in the second half after Daniel Cousin put his failed move to Fulham firmly behind him with a goal on the stroke of half-time.

Bayer Leverkusen got the best of an all-German affair, edging the home leg against Hamburg when Theofanis Gekas powerfully headed a Tranquillo Barnetta corner home in the 77th minute.

Jefferson Farfan pounced on a mistake from debutant Tottenham defender Gilberto to score the only goal of the game as PSV Eindhoven grabbed the initiative ahead of the return leg in Holland.