River are eight points off top spot, but go into the game on the back of a 2-0 away win over Rosario Central on Saturday.

Defender Federico Lussenhoff believes three points against Colon are crucial if they want to remain in the title hunt.

"We'll do our best to win. I think River's future in the tournament will depend on these three points up for grabs against Colon," he said.

Former Ajax forward Mauro Rosales believes San Lorenzo can be caught at the top of the table.

He said: "This is a tournament in which some teams play well and make it complicated for you, but there is no team who showed superiority."

"Just like River have lost lots of points, the teams on top can also lose. It is, and it will go on being, an even championship."

Colon, meanwhile, have been without a head coach since the resignation of Julio Cesar Falcioni on Saturday.

On Wednesday, the Sabaleros will be managed by Ramon Mantaras while the Board try to find a permanent replacement for Falcioni for the weekend.

This game should have been played on April 1, but floods in Santa Fe province forced the Argentinian Football Association to postpone it.

Also on Wednesday, Quilmes face fellow strugglers Racing Club in a relegation head-to-head.

Rock-bottom Quilmes are in desperate need of a victory if they are to climb out of the drop zone.

Alberto Fanesi's team are without a win in five games, while second-bottom Racing, who are under the temporary charge of Miguel Mico after Reinaldo Carlos Merlo's dismissal, have claimed just one victory in 11 outings.

This game was also postponed at beginning of April owing to security reasons.