The home side will need to be weary of a South team high on confidence after producing a 6-0 demolition of Hume City last week.

The Eagles are an attacking side but will be looking for striker Daniel Visevic to find the net again, unable to add to his five-goal tally since the Easter break.

South Melbourne is the competition's best travelling side, undefeated on the road and collecting three wins in its five trips.

Its midfield was superb last week, led by Joe Keenan, whose liveliness and creative influence on the wings or in the middle of the park has become crucial in South's two consecutive wins.

Also on Friday night, the top of the table Oakleigh will host a Sunshine George Cross side coming off a huge derby win against Green Gully.

The Georgies profited from a long-range strike by Kyle Joryeff to move within goal difference of the top five.

But the Cannons are coming off wins against fellow top five sides Hume City and Richmond in recent weeks.

The form of target striker Jerry Karpeh will be pleasing the fans and coaching staff with five goals this season.

Hume City will be looking to rebound from an embarrassing defeat last week when it hosts Altona Magic.

City has lost two in a row after its high-flying start to the season and will be hungry for a win against the out of sorts Magic.

Last year's champions will be glad to be away from home, collecting five of its seven points on the road.

But it is the only team in the competition to average less than a goal a game and will need to improve that strike rate if it is to overcome Hume.

The relegation-battling Dandenong Thunder will host Green Gully in another must-win game on Saturday night.

The Thunder got the three points last week courtesy of a Murat Abazi header but it remains in 11th.

Dandenong has already conceded a staggering 15 goals this season and will need to tighten up in the defensive third if it is to hold off a Gully side desperate for a win.

The derby loss last week leaves Gully mid-table but any run of successful results will quickly see it move into a finals position.

Melbourne Knights will host the Bentleigh Greens in a vital clash for both sides on Sunday.

The Knights have been hard to predict since overcoming a sluggish start to the season but disposed of Altona last week courtesy of a Kevin Townson double.

They host a Greens side coming off a week of rest after the postponement of its clash with Heidelberg last week.

Even with a game in hand, the promoted side has remained in the top five and will look to push that advantage at Knights Stadium.

In the final game of the round, Heidelberg will be looking to stay in touch with the rest of the league when it hosts Northcote City.

The Bergers were at Bentleigh last week and would be winless if not for the awarded fixture against South Melbourne.

City has struggled without striker Trent Rixon and has not scored in the three games since the Easter Break.

It is expected Rixon will miss at least one more week through injury so goals will need to come from wingers Bradley Norton and Jonathan Voulgaris or striker James Kalifatidis.