The result means Wanderers' remote hopes of reaching the last 16 are officially over, with one game to play at home to Shanghai SIPG.

It's been a woeful continental campaign for the former champions, having suffered 4-0 and 6-1 defeats to Urawa, along with a 5-1 thrashing by Shanghai.

The defeat comes days after crashing out of the A-League finals on penalties against Brisbane Roar.

GALLERY: Urawa v Wanderers match action

Wanderers were never in the game, trailing 3-0 at half-time, after goals to Takahiro Sekine, Zlatan Ljubijankic and Tadanari Lee.

Brendon Santalab had hit the crossbar in the first half in their best chance but Jumpei Kusukami, on his return to Japan, netted in the 66th minute.

Rafael Silva then took the game away from the visitors with strikes on 71 and 79 minutes to boost Urawa's hopes of topping Group F.

The Brazilian combined with Shinzo Koroki for a sensational sixth goal in stoppage-time.

GOALS

1-0 Urawa Reds: Takahiro Sekine 14’

Yuki Moto had time to slide the ball beautifully into the box for Sekine, who measured his shot into the far corner.

2-0 Urawa Reds: Zlatan Ljubijankic 18’

Yoshiaki Komai was able to run at the Wanderers defence before a gorgeous defence-splitting pass teed up Ljubijankic who got a toe to ball to divert past Vedran Janjetovic.

3-0 Urawa Reds: Tadanari Lee 43’

Komai’s pace allowed him to get in behind the Wanderers defence again and the winger unselfishly squared the ball across to Lee to tap into an open goal.

3-1 Western Sydney Wanderers: Jumpei Kusukami 66’

The Japanese winger received the ball just outside the box, taking on two defenders before sensationally chipping the ball over the keeper. Individual brilliance for Jumpei

4-1 Urawa Reds: Rafael Da Silva 71’

Silva started and finished the move, combining with Tadanari Lee on the edge of the box before making no mistake with his finish.

5-1 Urawa Reds: Rafael Silva 80’

A classic counter attack as a lofted ball over the top was controlled on his chest by Silva who then nonchalantly slotting the ball past Janjetovic.

6-1 Urawa Reds: Shinzo Koroki 90+4’

Another excellent, flowing move, with Silva’s clever back-heeled flick setting up Koroki for a simple finish past a stranded Janjetovic.