Cavani was injured during his side's 2-1 win over Portugal in the round of 16 on Sunday (AEST).

The game will take place at the Nizhny Novgorod Stadium at 12am Saturday (AEST).

Uruguay's starting XI:

Goalkeeper: Fernando Muslera;

Defenders: Jose Maria Gimenez, Diego Godin, Martin Caceres;

Midfielders: Diego Laxalt, Nahitan Nandez, Lucas Torreira, Rodrigo Bentancur, Matias Vecino;

Forwards: Luis Suarez, Cristhian Stuani.