The hosts were undone in a devastating 10-minute period before half-time as Nikos Spyropoulos netted and Djibril Cisse claimed a brace.

They pulled one back 10 minutes after the restart through Mario Budimir but Kostas Katsouranis rounded off the scoring for Pana 12 minutes from time, putting them one point behind the leaders.

Peral Javito scored as Aris Salonika won 1-0 at rivals PAOK, while Leonardo's early effort gave AEK Athens a 1-0 victory over Xanthi.

Iraklis played out a goalless draw at Kerkyra, while Maurice Dale netted the only goal of the game as Panseriakos beat Larissa.