While Roberto Mancini's Inter have dominated Italy's top flight in recent campaigns, the Rossoneri have been busy conquering the world.

The Nerazzurri go into the showdown encounter 22 points clear of Milan, who have three games in hand, but have already waved goodbye to their Scudetto hopes.

Inter have the best strikeforce and defensive line-up in the league but their remarkable form has been somewhat overshadowed by the glamorous achievements of the Rossoneri.

Having won the Champions League, the European Super Cup and clinched the FIFA Club World Cup trophy on Sunday, the Rossoneri take on Inter with their morale sky high.

"This is our last game of the year," said Kaka, who received the FIFA World Player of the Year award on Wednesday, having been honoured earlier this month with the European Player of the Year award.

"We have a great opportunity to reduce our deficit with Inter and we must do everything we can to clinch a victory."

A triumph by Milan will be welcomed by Roma, who are looking to return to winning ways after consecutive draws against Livorno and Torino left them seven points behind Inter.

Roma face Sampdoria on Saturday without injured captain Francesco Totti and Juventus, who are just one point behind the Eternal City giants, host Siena determined to leapfrog Roma in the table.

Udinese will be looking to avoid their third defeat in four games when Empoli visit the Stadio Friuli, while Fiorentina will be desperate to end their five-game winless run when they host bottom-side Cagliari.

The Sardinian outfit will be hoping the arrival of former coach Marco Giampaolo, who replaced Nedo Sonetti on Wednesday, will spark their season into life.

Palermo will be looking to maintain their sixth position in the table with a home victory against Lazio, but a slip by the Sicilian giants would see promoted club Napoli overtake them in the standings as long as they beat Torino.

Genoa will fancy their chances against Parma, with the Ducale club having failed to win a game on the road this campaign and Livorno take on Atalanta knowing that a defeat could see them drop into the relegation zone.

Strugglers Reggina already know they will spend Christmas in the bottom three, but will battle it out against Catania in the hope of clinching their second win of the campaign.