Champions Bursaspor fought back from two goals down to preserve their unbeaten record with a 2-2 draw at Antalyaspor.
Antalyaspor, unbeaten at home this season, roared into a 2-0 lead with first-half goals from Uguer Inceman (23) and Seras (44).
Ali Tandogan pulled a goal back for the champions six minutes after the restart and Ozan Ipek levelled 16 minutes from the end.
Bursaspor had Giani Kirita sent off four minutes from the end, but they had already done enough to earn a draw that edges them a point clear of Kayserispor at the top.
Fenerbahce strengthened their hold on fourth place with a 4-2 win over Eskisehirspor, in a game which saw both sides reduced to 10 men on the stroke of half-time.
Fener led 2-1 after 18 minutes with a fourth-minute Alex penalty and Semih Senturk strike sandwiching Sezer Ozturk's equaliser on 11 minutes.
The match came to life just before the break when Gokhan Gonul fired Fener 3-1 ahead while their defender Diego Lugano and away goalscorer Ozturk both saw red.
Serdar Ozbayraktar pulled a goal back on 65 minutes but Senturk's second finally sealed an eventful encounter.
Emmanuel Emenike struck a hat-trick to move Karabukspor up to fifth with a 3-0 win against Bucaspor while second-half goals from Olcan Adin (74) and Saraiva Ivan (90) were enough for Gaziantepspor to win 2-0 at Ankaragucu.