The police operation was based in Cremona, with arrests taking place across more than 10 cities.

Former Lazio captain Giuseppe Signori was reportedly among those arrested, along with lower-league players, club executives and betting operators.

"Do you not have mercy in this situation? Have mercy. I cannot say anything, I will meet my attorney and then he will speak for me," ex-Italy striker Signori told Corriere dello Sport by telephone before going to police headquarters for questioning in Bologna.

The police investigation began last November after a Serie C match between Cremonese and Paganese. Cremonese players allegedly had their drinks spiked to prevent them from playing well.

Speaking at a press conference at the city's police headquarters, Cremona public prosecutor Roberto Di Martino said: "It is understood that a substance was mixed with water, a tranquilliser, that the Cremonese players drank during the game or before."